The latest scientific evidence confirms the effectiveness of the ‘double’ stimulation approach of the ovaries used in medically assisted reproduction cycles, indicated for women who need an optimization of the ovarian response to the stimulation, such as cancer patients, or of an advanced maternal age: a multicenter study published in the journal ‘Human Reproduction’, first author Dr Alberto Vaiarelli, fertility specialist of Genera center in Rome, highlights that babies born from blastocysts obtained in the luteal phase have the same perinatal outcomes as those born from blastocysts obtained in the follicular phase.

Scientific research, which continues to work to find new ways for patients who have less chances of success, has recently implemented new ovarian stimulation protocols aimed at a more efficient management of patients with poor prognosis and exposed to negative outcomes with conventional approaches. The “DuoStim” is among the most promising.

It consists of combining two consecutive stimulations in the follicular and luteal phases of the same ovarian cycle, so that the number of oocytes collected can be increased and embryos produced in a short period of time. Currently, data from several independent studies have highlighted the consistency and reproducibility of this approach, and the new work now confirms that reproductive outcomes (clinical, obstetric and perinatal) are identical among euploid blastocysts derived from follicular phase stimulation and luteal phase stimulation.

“The new study on ‘Human Reproduction’, like others that our group has published in the past – says Alberto Vaiarelli – further supports the safety of this new stimulation protocol, which is especially indicated for patients who need to achieve the transfer of an euploid blastocyst in the shortest time possible, due to reasons such as advanced maternal age (this is often used in women ‘over 40’ with excellent results) and/or a reduced ovarian reserve.

It is the first study that examines reproductive outcomes, and therefore the babies born, thanks to this technique. It is as if, taking advantage of both the follicular and luteal phases of an ovarian cycle, starting a second stimulation 5 days after the first egg retrieval, it is possible to significantly increase the chances of success, almost doubling them, given that they we carry out ‘two simulations in one’. These new findings encourage further clinical trials and research to customize the protocol in specific patient populations, many of which may benefit from unconventional protocols”.

More information:

Follicular versus luteal phase ovarian stimulation

Double Stimulation in the Same Ovarian Cycle

Luteal phase

DuoStim – a reproducible strategy

The euploid blastocysts obtained after luteal phase stimulation